GNF2133 hydrochloride is a selective and orally active inhibitor of DYRK1A, exhibiting an IC50 of 0.0062 µM for DYRK1A while remaining inactive against GSK3β at concentrations exceeding 50 µM. This compound demonstrates significant efficacy in enhancing proliferation and functioning of both rat and human primary β-cells. Additionally, GNF2133 hydrochloride enhances glucose disposal and promotes insulin secretion, making it a valuable tool for research in type 1 diabetes.
GNF2133 hydrochloride is a selective and orally active inhibitor of DYRK1A, exhibiting an IC50 of 0.0062 µM for DYRK1A while remaining inactive against GSK3β at concentrations exceeding 50 µM. This compound demonstrates significant efficacy in enhancing proliferation and functioning of both rat and human primary β-cells. Additionally, GNF2133 hydrochloride enhances glucose disposal and promotes insulin secretion, making it a valuable tool for research in type 1 diabetes.
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