Fig. 1 · Structure
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GOT1 inhibitor-1
GOT1 Inhibitor
GOT1 Inhibitor-1 is a potent, non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1), with an IC50 of 8.2 µM. This tryptamine-based derivative modulates energy metabolism and reactive oxygen species (ROS) balance, making it a valuable tool for studying cellular processes. It is particularly relevant for research focused on pancreatic ductal adenocarcinoma (PDAC) and related metabolic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 732973-87-4 |
| Applications | GOT1 Inhibitor |
| Formula | C19H19ClN4O |
| Molecular Weight | 354.83 |
| SMILES | O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=C(Cl)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.