Fig. 1 · Structure
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GPR40 agonist 5
Antidiabetic Agent
GPR40 agonist 5 is a potent agonist of G protein-coupled receptor 40 (GPR40), exhibiting an EC50 of 47 nM. This compound demonstrates significant antidiabetic activity by reducing blood glucose levels and enhancing glucose tolerance, making it relevant for research in type 2 diabetes models. Additionally, GPR40 agonist 5 functions as a click chemistry reagent, featuring an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2443384-60-7 |
| Applications | Antidiabetic Agent |
| Formula | C27H24N2O4 |
| Molecular Weight | 440.49 |
| SMILES | CC#CC(C1=CC=C(C=C1)OCC2=CN3C=C(N=C3C=C2)C4=CC=C(C=C4)OC)CC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.