Fig. 1 · Structure
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GPVI antagonist 3
GPVI Antagonist
GPVI Antagonist 3 is a selective antagonist targeting Glycoprotein VI (GPVI), a key receptor involved in collagen-mediated platelet activation. Its inhibitory potency is characterized by IC50 values of 1.01 μM for collagen, 1.92 μM for collagen-related peptide (CRP), 7.24 μM for convulxin, and 51.74 μM for thrombin. This compound is of particular interest for antithrombotic research as it offers potential as a novel antiplatelet agent, providing insights into the regulation of platelet function and thrombosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 901654-94-2 |
| Applications | GPVI Antagonist |
| Formula | C22H23N3O4 |
| Molecular Weight | 393.44 |
| SMILES | O=C1N(CCCO)C(C2=CC=C(OC)C=C2)C3=C1NN=C3C4=CC(C)=CC=C4O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.