GR-4991W93 is an orally active partial agonist of the 5HT1B and 5HT1D receptors, showing pIC50 values of 6.95 and 7.80, respectively. This compound exhibits significant inhibition of electrically evoked plasma extravasation in guinea pig models, demonstrating its pharmacological potential in modulating neurogenic inflammation. GR-4991W93 is suitable for use in migraine research, offering insights into the mechanisms underlying this condition.
GR-4991W93 is an orally active partial agonist of the 5HT1B and 5HT1D receptors, showing pIC50 values of 6.95 and 7.80, respectively. This compound exhibits significant inhibition of electrically evoked plasma extravasation in guinea pig models, demonstrating its pharmacological potential in modulating neurogenic inflammation. GR-4991W93 is suitable for use in migraine research, offering insights into the mechanisms underlying this condition.
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