Fig. 1 · Structure
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GR-4991W93
5HT1B/1D Receptor Agonist
GR-4991W93 is an orally active partial agonist of the 5HT1B and 5HT1D receptors, showing pIC50 values of 6.95 and 7.80, respectively. This compound exhibits significant inhibition of electrically evoked plasma extravasation in guinea pig models, demonstrating its pharmacological potential in modulating neurogenic inflammation. GR-4991W93 is suitable for use in migraine research, offering insights into the mechanisms underlying this condition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 171549-56-7 |
| Applications | 5HT1B/1D Receptor Agonist |
| Formula | C18H23N3O2 |
| Molecular Weight | 313.39 |
| SMILES | CN(C)[C@H](C1)C[C@@H]1C2=CNC3=CC=C(C[C@@H]4NC(OC4)=O)C=C32 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.