GR125487 is a highly selective antagonist of the 5-HT4 receptor, exhibiting a Kd value of 0.1 nM. It demonstrates minimal binding affinity for 5-HT3 receptors (Kd > 1 μM), ensuring specificity in its action. GR125487 effectively inhibits the memory-enhancing effects of BIMU1 without significantly affecting baseline social memory. This compound is valuable for investigating mechanisms underlying social olfactory memory and related cognitive processes.
GR125487 is a highly selective antagonist of the 5-HT4 receptor, exhibiting a Kd value of 0.1 nM. It demonstrates minimal binding affinity for 5-HT3 receptors (Kd > 1 μM), ensuring specificity in its action. GR125487 effectively inhibits the memory-enhancing effects of BIMU1 without significantly affecting baseline social memory. This compound is valuable for investigating mechanisms underlying social olfactory memory and related cognitive processes.
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