Fig. 1 · Structure
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GRK2 Inhibitor 1
GRK2 Inhibitor
GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a selective inhibitor of GRK2 and β-ARK1, crucial targets in the modulation of signal transduction pathways. This compound is known to reverse dopamine inhibition (DIR), impacting neuronal sensitivity within addiction-related brain circuits. Additionally, GRK2 Inhibitor 1 effectively counters serotonin-induced and neurotensin-induced DIR reversal, making it a valuable tool for research into neuropharmacology and addiction mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 24269-96-3 |
| Applications | GRK2 Inhibitor |
| Formula | C12H9NO6 |
| Molecular Weight | 263.20 |
| SMILES | O=C(OC)C1=CC=C(O1)/C=C/C2=CC=C(O2)[N+]([O-])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.