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GRK2i

Catalog No.: A60437
Gβγ Antagonist
GRK2i is a selective Gβγ antagonist that inhibits Gβγ-mediated signaling pathways. This peptide corresponds to the Gβγ-binding domain of G-protein-coupled receptor kinase 2 (GRK2), making it a valuable tool for studying G-protein signaling mechanisms. Its application includes investigating the role of Gβγ subunits in various cellular processes and identifying potential therapeutic targets related to G-protein-coupled receptor signaling.
GRK2i 148505-03-7 Gβγ Antagonist
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Size Price Stock Qty
1mg
$945.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGRK2i is a selective Gβγ antagonist that inhibits Gβγ-mediated signaling pathways. This peptide corresponds to the Gβγ-binding domain of G-protein-coupled receptor kinase 2 (GRK2), making it a valuable tool for studying G-protein signaling mechanisms. Its application includes investigating the role of Gβγ subunits in various cellular processes and identifying potential therapeutic targets related to G-protein-coupled receptor signaling.
Product Information
Catalog NumA60437
FormulaC153H256N50O41S
Molecular Weight3484.08
CAS Number148505-03-7
Sequence shorteningWKKELRDAYREAQQLVQRVPKMKNKPRS
SMILESC([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCCNC(=N)N)=O)CCC3)CCCCN)=O)CC(N)=O)=O)CCCCN)=O)CCSC)=O)CCCCN)=O)CCC2)[C@H](C)C)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)[C@H](C)C)=O)CC(C)C)=O)CCC(N)=O)=O)CCC(N)=O)=O)C)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)=O)C)=O)CC(O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCC(O)=O)=O)CCCCN)=O)CCCCN)=O)N)C=4C=5C(NC4)=CC=CC5
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GPCR/G Protein > GRK