Fig. 1 · Structure
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GRK5-IN-2
GRK5 Inhibitor
GRK5-IN-2 is a selective inhibitor of G-protein-coupled receptor kinase 5 (GRK5), demonstrating an IC50 of 49.7 μM. This pyridine-based bicyclic compound modulates insulin expression and secretion, making it a valuable tool for research focused on metabolic diseases and associated pathways. Its inhibitory properties can aid in the exploration of GRK5's role in various physiological and pathological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1642839-27-7 |
| Applications | GRK5 Inhibitor |
| Formula | C20H20N4O4 |
| Molecular Weight | 380.40 |
| SMILES | COC1=C(OC)C(OC)=CC(NC2=CC3=C(N=C(C4=CC=CO4)N3C)C=N2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.