Fig. 1 · Structure
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GRN-529
mGluR Modulator
GRN-529 is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It has demonstrated the ability to modulate sleep-wake activity and exhibits anxiolytic effects in rodent models. This compound is of significant interest for research into sleep disorders and anxiety-related conditions, providing insights into mGluR5-targeted therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1253291-12-1 |
| Applications | mGluR Modulator |
| Formula | C22H15F2N3O2 |
| Molecular Weight | 391.37 |
| SMILES | O=C(N1CC2=NC=CC=C2C1)C3=CC=C(C(C#CC4=NC=CC=C4)=C3)OC(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.