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GRPR antagonist-1

GRPR Antagonist

GRPR antagonist-1 is a potent antagonist of the gastrin releasing peptide receptor (GRPR), demonstrating cytotoxic effects in various cancer cell lines with IC50 values of 4.97 μM in PC3, 4.36 μM in Pan02, and 3.40 μM in HGC-27 cells. This compound disrupts HGC-27 cell viability by downregulating Bcl-2 and upregulating Bax, leading to apoptosis. Its mechanism and efficacy make it a valuable tool for cancer research, particularly in studies targeting GRPR signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	3052544-28-9
Applications	GRPR Antagonist
Formula	C₂₉H₃₃F₃N₄O₄
Molecular Weight	558.59
SMILES	CC(C)(OC(N1CCN(CC1)C([C@H](CC2=CNC3=C2C=CC=C3)NC(CC4=CC=C(C=C4)C(F)(F)F)=O)=O)=O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.