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GS-1291269

KHK Inhibitor

GS-1291269 is a selective inhibitor of ketohexokinase (KHK), exhibiting potent inhibitory activity with IC50 values of 0.38 nM for KHK-C and 2.1 nM for KHK-A. This compound effectively reduces fructose-1-phosphate (F1P) levels in liver and kidney tissues during fructose challenge studies in rats. GS-1291269 is a valuable tool for investigating mechanisms underlying kidney disease and metabolic dysfunction-related steatotic liver disease (MASLD).

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2845278-33-1
Applications	KHK Inhibitor
Formula	C₂₀H₁₉F₅N₄O₂S
Molecular Weight	474.45
SMILES	FC1(F)C2=NC(N3[C@@H](C(F)(F)F)CC3)=NC(C4=CC=C(C5(CS(C5)(=O)=O)N)C=C4)=C2CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.