Fig. 1 · Structure
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GSK-114
TNNI3K Inhibitor
GSK-114 is a selective inhibitor of TNNI3K (cardiac troponin I-interacting kinase), demonstrating an IC50 of 25 nM. This compound exhibits a remarkable 40-fold selectivity for TNNI3K over B-Raf kinase (IC50 = 1 μM). TNNI3K, a member of the tyrosine-like kinase family, is primarily expressed in cardiac tissue, making GSK-114 a valuable tool for research focused on cardiac function and related pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1301761-96-5 |
| Applications | TNNI3K Inhibitor |
| Formula | C19H23N5O4S |
| Molecular Weight | 417.48 |
| SMILES | O=S(NC)(C1=CC=C(N(C)C)C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.