Fig. 1 · Structure
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GSK-1440115
UII receptor (UT) antagonist
GSK-1440115 is an antagonist of the Urotensin II receptor (UT), exhibiting an IC50 value of 82.3 nM. This compound effectively inhibits UT signaling, making it a valuable tool for research into cardiovascular diseases and conditions associated with inflammation. Its ability to modulate Urotensin II pathways supports investigations into potential therapeutic applications for UT-related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1003878-16-7 |
| Applications | UII receptor (UT) antagonist |
| Formula | C30H29Cl2N3O6 |
| Molecular Weight | 598.47 |
| SMILES | O=C(C1=CC=C(C2=CC=C([C@@H](N(C(CN3C(COC4=CC(Cl)=C(Cl)C=C34)=O)=O)C)CN5CCOCC5)C=C2)C=C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.