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GSK-163090 dihydrochloride

5-HT1A/1B/1D Receptor Antagonist

GSK-163090 dihydrochloride is a potent and selective antagonist of the 5-HT1A, 5-HT1B, and 5-HT1D serotonin receptors, exhibiting pKi values of 9.4, 8.5, and 9.7, respectively. Additionally, it inhibits the serotonin reuptake transporter (SerT) with a pKi value of 6.1. This compound demonstrates significant antidepressant and anxiolytic effects, making it a valuable tool for research in neuropharmacology and the investigation of serotonin-related disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	844903-52-2
Applications	5-HT1A/1B/1D Receptor Antagonist
Formula	C₂₅H₃₁Cl₂N₅O
Molecular Weight	488.45
SMILES	O=C1NCCN1C2=CC=CC(CCN3CCN(C4=C5C=CC(C)=NC5=CC=C4)CC3)=C2.Cl.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.