GSK-163090 dihydrochloride is a potent and selective antagonist of the 5-HT1A, 5-HT1B, and 5-HT1D serotonin receptors, exhibiting pKi values of 9.4, 8.5, and 9.7, respectively. Additionally, it inhibits the serotonin reuptake transporter (SerT) with a pKi value of 6.1. This compound demonstrates significant antidepressant and anxiolytic effects, making it a valuable tool for research in neuropharmacology and the investigation of serotonin-related disorders.
GSK-163090 dihydrochloride is a potent and selective antagonist of the 5-HT1A, 5-HT1B, and 5-HT1D serotonin receptors, exhibiting pKi values of 9.4, 8.5, and 9.7, respectively. Additionally, it inhibits the serotonin reuptake transporter (SerT) with a pKi value of 6.1. This compound demonstrates significant antidepressant and anxiolytic effects, making it a valuable tool for research in neuropharmacology and the investigation of serotonin-related disorders.
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