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- Praneeth Siripurapu, .et al. Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration, J Biol Chem, 2017, Oct 20; 292(42): 17482-17495 PMID: 28864771
Biological Activity
GSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.53 mL | 87.63 mL | 175.25 mL |
| 0.5 mM | 3.51 mL | 17.53 mL | 35.05 mL |
| 1 mM | 1.75 mL | 8.76 mL | 17.53 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.51 mL |
*The above data is based on the productmolecular weight 570.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12348 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 850664-21-0 |
| Formula | C29H30N8O5 |
| M. Wt | 570.6 |
| Purity | >98% |
| Synonyms | GSK269962,GSK-269962, GSK269962A, GSK-269962A |
| SMILES | CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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