GSK 269962

Catalog No.: A12348

ROCK inhibitor

GSK 269962

GSK 269962 Chemical Structure

CAS NO. 850664-21-0

GSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $150.00

Special Price $120.00

25 mg

Regular Price: $350.00

Special Price $280.00

50 mg

Regular Price: $600.00

Special Price $480.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Praneeth Siripurapu, .et al. Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration, J Biol Chem, 2017, Oct 20; 292(42): 17482-17495 PMID: 28864771

Biological Activity

GSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.53 mL 87.63 mL 175.25 mL
0.5 mM 3.51 mL 17.53 mL 35.05 mL
1 mM 1.75 mL 8.76 mL 17.53 mL
5 mM 0.35 mL 1.75 mL 3.51 mL

*The above data is based on the productmolecular weight 570.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12348
Actions Inhibitor
CAS No. 850664-21-0
Formula C29H30N8O5
M. Wt 570.6
Purity >98%
Synonyms GSK269962,GSK-269962, GSK269962A, GSK-269962A
SMILES CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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