Fig. 1 · Structure
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GSK 3008348 hydrochloride
αvβ6 Antagonist
GSK 3008348 hydrochloride is a small molecule antagonist of the integrin αvβ6, with IC50 values of 1.50 nM for αvβ6 and varying degrees of activity against αvβ1, αvβ3, αvβ5, and αvβ8. This compound effectively inhibits TGF-β activation, which is crucial in the progression of fibrosis. Additionally, GSK 3008348 hydrochloride blocks the interaction of foot-and-mouth disease virus (FMDV) with the αvβ6 receptor, preventing viral entry into host cells. Its applications extend to the study of pulmonary fibrosis and diverse cancer research, making it a valuable tool in therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1629249-40-6 |
| Applications | αvβ6 Antagonist |
| Formula | C29H38ClN5O2 |
| SMILES | O=C(O)C[C@@H](C1=CC(N2N=C(C)C=C2C)=CC=C1)CN3C[C@H](CCC(N4)=CC=C5C4=NCCC5)CC3.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.