Fig. 1 · Structure
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GSK 690 Hydrochloride
Histone Demethylase Inhibitor
GSK 690 Hydrochloride is a reversible inhibitor of lysine-specific demethylase 1 (LSD1), demonstrating a Kd value of 9 nM and a biochemical IC50 of 37 nM. This compound effectively disrupts histone demethylation, impacting gene expression regulation. It is valuable for research applications focused on epigenetic modifications, cancer biology, and the study of LSD1's role in various metabolic processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2436760-79-9 |
| Applications | Histone Demethylase Inhibitor |
| Formula | C24H24ClN3O |
| Molecular Weight | 405.92 |
| SMILES | N#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.