GSK-872 hydrochloride is a potent inhibitor of receptor-interacting protein kinase 3 (RIPK3), exhibiting an IC50 of 1.8 nM for binding to the RIP3 kinase domain and an IC50 of 1.3 nM for inhibiting its kinase activity. This compound effectively reduces RIPK3-mediated necroptosis and inhibits the cytoplasmic translocation and expression of HMGB1. Additionally, GSK-872 hydrochloride has been shown to alleviate brain edema and neurological deficits in models of early brain injury, making it a valuable tool for studying necroptosis and related pathophysiological processes.
GSK-872 hydrochloride is a potent inhibitor of receptor-interacting protein kinase 3 (RIPK3), exhibiting an IC50 of 1.8 nM for binding to the RIP3 kinase domain and an IC50 of 1.3 nM for inhibiting its kinase activity. This compound effectively reduces RIPK3-mediated necroptosis and inhibits the cytoplasmic translocation and expression of HMGB1. Additionally, GSK-872 hydrochloride has been shown to alleviate brain edema and neurological deficits in models of early brain injury, making it a valuable tool for studying necroptosis and related pathophysiological processes.
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