Fig. 1 · Structure
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GSK-9772
Liver X Receptor Modulator
GSK-9772 is a potent Liver X Receptor (LXR) β modulator that acts as an anti-inflammatory agent by targeting the receptor's transcriptional repression region (IC50 = 30 nM). By binding to LXR, it effectively inhibits the expression of pro-inflammatory genes, making it a valuable tool for investigating inflammatory and neurodegenerative diseases. Its selective modulation of LXR β highlights its potential applications in understanding lipid metabolism and related pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 928035-84-1 |
| Applications | Liver X Receptor Modulator |
| Formula | C20H19Cl2F6NO2 |
| Molecular Weight | 490.27 |
| SMILES | OC1=C(Cl)C=C(CN(CCCC)C2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2)C=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.