Fig. 1 · Structure
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GSK040
BET BD2 Inhibitor
GSK040 is a potent and highly selective inhibitor of the BET BD2 domain, exhibiting a pIC50 of 8.3. This compound demonstrates over 5000-fold selectivity for BET BD2 compared to BET BD1, with a pIC50 of 4.6. GSK040 is suitable for research applications targeting oncology and immunological diseases, facilitating the exploration of BET protein functions in these areas.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2752331-09-0 |
| Applications | BET BD2 Inhibitor |
| Formula | C29H34N4O4 |
| Molecular Weight | 502.60 |
| SMILES | O=C(C(C=C1C)=CN(C)C1=O)N([C@H](C2CCOCC2)C(NC)=O)C[C@H](C3=CC=CC=C3)C4=NC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.