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Aurora Kinase B/C inhibitor
GSK1070916 is a potent Aurora B/C kinase inhibitor (with IC50 of 3.5 nM/6.5 nM) with broad antitumor activity in tissue culture cells and human tumor xenograft models.
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| Target | Activity | Value |
|---|---|---|
| AuroraB-INCENP | IC50 | 3.5nM |
| AuroraC-INCENP | IC50 | 6.5nM |
| FLT1 | IC50 | 42nM |
| Tie-2 | IC50 | 59nM |
| SIK | IC50 | 70nM |
| FLT4 | IC50 | 74nM |
| FGFR1 | IC50 | 76nM |
| AuroraA-TPX2 | IC50 | 1.1μM |
8 targets · Scroll to view more
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| A549 | EC50 | 7 nM | Antiproliferative activity against human A549 cells after 6 to 7 days by celltiter-glo luminescence assay in absence of 70% human serum albumin | [PMID: 20420387] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 942918-07-2 |
| Applications | Aurora Kinase B/C inhibitor |
| Formula | C30H33N7O |
| Molecular Weight | 507.63 |
| SMILES | CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C |
| Solvent | Reported Solubility |
|---|---|
| DMSO | 91 mg/mL (179.26 mM) |
| Water | Insoluble |
| Ethanol | 8 mg/mL (15.75 mM) |
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
