GSK1070916

Catalog No.: A11168

Aurora Kinase B/C inhibitor

GSK1070916 Chemical Structure

CAS NO. 942918-07-2

GSK1070916 is a potent Aurora B/C kinase inhibitor (with IC50 of 3.5 nM/6.5 nM) with broad antitumor activity in tissue culture cells and human tumor xenograft models.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$150.00
50 mg
$400.00
100 mg
$700.00
10mM * 1mL in DMSO
$100.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK1070916 is a potent Aurora B/C kinase inhibitor (with IC50 of 3.5 nM/6.5 nM) with broad antitumor activity in tissue culture cells and human tumor xenograft models.

Targets
Target Value
AuroraB-INCENPIC50: 3.5nM
AuroraC-INCENPIC50: 6.5nM
FLT1IC50: 42nM
Tie-2IC50: 59nM
SIKIC50: 70nM
FLT4IC50: 74nM
FGFR1IC50: 76nM
AuroraA-TPX2IC50: 1.1μM
In vitro (25°C) DMSO 102 mg/mL (200.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol 102 mg/mL (200.93 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.7 mL 98.5 mL 196.99 mL
0.5 mM 3.94 mL 19.7 mL 39.4 mL
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL

*The above data is based on the productmolecular weight 507.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11168
Actions Inhibitor
M. Wt 507.63
Formula C30H33N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 942918-07-2
Synonyms GSK-1070916
SMILES CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C

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