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GSK126

Catalog No.: A11757
EZH2 inhibitor
Adooq's GSK126 has been cited by 4 publications
GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity, decreases global H3K27me3 levels and reactivates silenced PRC2 target genes.
GSK126
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Product Name Price Stock Qty
GSK126 2mg
Special Price $32.00 Regular Price $40.00
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GSK126 5mg
Special Price $48.00 Regular Price $60.00
In stock
GSK126 10mg
Special Price $72.00 Regular Price $90.00
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GSK126 25mg
Special Price $128.00 Regular Price $160.00
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Adooq Products cited in reputable paper
Adooq's GSK126 has been cited by 4 publications
  • Lucy E. Dawson, .et al. , Sarcoma, 2020, 2020: 8647981 PMID: 32300280
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Dupret B, .et al. , Biochim Biophys Acta Gene Regul Mech, 2017, Oct;1860(10):1079-1093 PMID: 28887218
  • Theresa Baker, .et al. , Oncotarget, 2015, Oct 20; 6(32): 32646-32655 PMID: 26360609
    • Biological Activity
    Discription GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity, decreases global H3K27me3 levels and reactivates silenced PRC2 target genes.
    Targets
    Target Value
    Product Information
    Catalog Num A11757
    Formula C31H38N6O2
    Molecular Weight 526.67
    CAS Number 1346574-57-9
    SMILES CC[C@H](C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C
    Synonyms GSK 126, GSK-126
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Solubility
    In vitro (25°C) DMSO Warmed: 3 mg/mL (5.69 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4% DMSO+corn oil 0.4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.99 mL 94.94 mL 189.87 mL
    0.5 mM 3.8 mL 18.99 mL 37.97 mL
    1 mM 1.9 mL 9.49 mL 18.99 mL
    5 mM 0.38 mL 1.9 mL 3.8 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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    Epigenetics > Histone Methyltransferase
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