GSK1324726A (I-BET726)

Catalog No.: A14133

BET inhibitor

GSK1324726A (I-BET726) Chemical Structure

CAS NO. 1300031-52-0

GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM).

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$200.00
25 mg
$380.00
10mM * 1mL in DMSO
$165.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM).
Targets
BRD4 BRD3 BRD2
22 nM31 nM41 nM
In vitro DMSO 86 mg/mL (197.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 86 mg/mL (197.74 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.99 mL 114.97 mL 229.93 mL
0.5 mM 4.6 mL 22.99 mL 45.99 mL
1 mM 2.3 mL 11.5 mL 22.99 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

*The above data is based on the productmolecular weight 434.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14133
Actions Inhibitor
M. Wt 434.91
Formula C25H23ClN2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1300031-52-0
Synonyms I-BET726, GSK 1324726A, GSK-1324726A, I-BET 726
SMILES CC1CC(C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)O)NC4=CC=C(C=C4)Cl

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