GSK1324726A (I-BET726)

GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM).
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Product Name Price Stock Qty
GSK1324726A 5mg
$104.00
In stock
GSK1324726A 10mg
$177.00
In stock
GSK1324726A 25mg
$312.00
In stock
GSK1324726A 10mM * 1mL in DMSO
$165.00
In stock
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Adooq Products cited in reputable paper
Adooq's GSK1324726A (I-BET726) has been cited by 1 publications
  • Zhengjun Liu, .et al. , Cell Death Dis, 2020, May 5;11(5):318 PMID: 32371868
  • Biological Activity
    Discription GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM).
    Targets
    Target Value
    Product Information
    Catalog Num A14133
    Formula C25H23ClN2O3
    Molecular Weight 434.91
    CAS Number 1300031-52-0
    SMILES CC1CC(C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)O)NC4=CC=C(C=C4)Cl
    Synonyms I-BET726, GSK 1324726A, GSK-1324726A, I-BET 726
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 77 mg/mL (177.05 mM)
    Water Insoluble
    Ethanol 77 mg/mL (177.05 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.99 mL 114.97 mL 229.93 mL
    0.5 mM 4.6 mL 22.99 mL 45.99 mL
    1 mM 2.3 mL 11.5 mL 22.99 mL
    5 mM 0.46 mL 2.3 mL 4.6 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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