Fig. 1 · Structure
Documents & Downloads
GSK2163632A
GRK Inhibitor
GSK2163632A is a selective inhibitor of G protein-coupled receptor kinases (GRK), specifically targeting GRK1 and GRK5. This compound demonstrates significant biological activity in the modulation of signaling pathways relevant to heart failure and Parkinson's disease. Additionally, GSK2163632A also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R, making it a valuable tool for elucidating mechanisms associated with these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1123163-20-1 |
| Applications | GRK Inhibitor |
| Formula | C27H32N8O3S |
| Molecular Weight | 548.66 |
| SMILES | O=C(N)C1=C(C=CS1)NC2=C3C(NC=C3)=NC(NC4=CC5=C(C(C)(CCN5C(CN(C)C)=O)C)C=C4OC)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.