Fig. 1 · Structure
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GSK2188764
ROP18 Inhibitor
GSK2188764 is a potent inhibitor of the Toxoplasma gondii rhoptry protein 18 (ROP18), exhibiting an IC50 value of 7.49 μM. It effectively inhibits the serine-threonine kinase activity of ROP18 in vitro. This compound is valuable for research focused on the mechanisms of toxoplasmosis and the development of potential therapeutic strategies against Toxoplasma gondii infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1849587-68-3 |
| Applications | ROP18 Inhibitor |
| Formula | C17H16Cl2N6O |
| Molecular Weight | 391.26 |
| SMILES | O=C1NC=CC=2N=C(N=C(NC=3C=C(Cl)C=C(Cl)C3)C12)NC4CNCC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.