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Biological Activity
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.81 mL | 79.04 mL | 158.08 mL |
| 0.5 mM | 3.16 mL | 15.81 mL | 31.62 mL |
| 1 mM | 1.58 mL | 7.9 mL | 15.81 mL |
| 5 mM | 0.32 mL | 1.58 mL | 3.16 mL |
*The above data is based on the productmolecular weight 632.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15097 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1415560-64-3 |
| Formula | C29H27F3N4O7S |
| M. Wt | 632.61 |
| Purity | >98% |
| Synonyms | GSK-256066, GSK 256066 |
| SMILES | CC1=C2C(=CC(=C1)S(=O)(=O)C3=CC=CC(=C3)C(=O)N(C)C)C(=C(C=N2)C(=O)N)NC4=CC(=CC=C4)OC.C(=O)(C(F)(F)F)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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