GSK256066 2,2,2-trifluoroacetic acid

Catalog No.: A15097

PDE Inhibitor

GSK256066 2,2,2-trifluoroacetic acid

GSK256066 2,2,2-trifluoroacetic acid Chemical Structure

CAS NO. 1415560-64-3

GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.

Availability: In stock

Package Price Qty
10 mg
$200.00
50 mg
$600.00
500 mg
$1,700.00
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Biological Activity

GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.81 mL 79.04 mL 158.08 mL
0.5 mM 3.16 mL 15.81 mL 31.62 mL
1 mM 1.58 mL 7.9 mL 15.81 mL
5 mM 0.32 mL 1.58 mL 3.16 mL

*The above data is based on the productmolecular weight 632.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15097
Actions Inhibitor
CAS No. 1415560-64-3
Formula C29H27F3N4O7S
M. Wt 632.61
Purity >98%
Synonyms GSK-256066, GSK 256066
SMILES CC1=C2C(=CC(=C1)S(=O)(=O)C3=CC=CC(=C3)C(=O)N(C)C)C(=C(C=N2)C(=O)N)NC4=CC(=CC=C4)OC.C(=O)(C(F)(F)F)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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