Fig. 1 · Structure
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GSK2945
Cytochrome P450 Activator
GSK2945 is a potent activator of cytochrome P450, specifically enhancing cholesterol 7α-hydroxylase (CYP7A1) activity. It demonstrates high specificity as a Rev-erbα antagonist, with EC50 values of 21.5 μM for mouse and 20.8 μM for human. This compound is primarily utilized in research focused on cholesterol metabolism and its regulatory mechanisms, offering insights into lipid homeostasis and related metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1438071-12-5 |
| Applications | Cytochrome P450 Activator |
| Formula | C20H18Cl2N2O2S |
| Molecular Weight | 421.34 |
| SMILES | O=[N+](C1=CC=C(CN(CC2=CC=C(Cl)C=C2C)CC3=CC=C(Cl)C=C3)S1)[O-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.