Signaling Pathway
Product type
Important Notice: For research use only. We do not sell to patients.
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| Discription | GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC= 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence). | |||||
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| Cell Research |
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| Catalog Num | A13114 |
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| Formula | C31H39N7O2 |
| Molecular Weight | 541.69 |
| CAS Number | 1346704-33-3 |
| SMILES | CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C |
| Synonyms | GSK-343, GSK 343 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | Warmed: 1 mg/mL (1.84 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (5.54 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.46 mL | 92.3 mL | 184.61 mL |
| 0.5 mM | 3.69 mL | 18.46 mL | 36.92 mL |
| 1 mM | 1.85 mL | 9.23 mL | 18.46 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.69 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
