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GSK343

Catalog No.: A13114
EZH2 inhibitor
Adooq's GSK343 has been cited by 2 publications
GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC= 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).
GSK343
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Product Name Price Stock Qty
GSK343 5mg
Special Price $40.00 Regular Price $50.00
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GSK343 10mg
Special Price $64.00 Regular Price $80.00
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GSK343 25mg
Special Price $120.00 Regular Price $150.00
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GSK343 50mg
Special Price $200.00 Regular Price $250.00
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Adooq Products cited in reputable paper
Adooq's GSK343 has been cited by 2 publications
  • Yang PM, .et al. , Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
  • Nie L, .et al. , Nat Commun, 2019, Nov 8;10(1):5114 PMID: 31704972
    • Biological Activity
    Discription GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC= 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).
    Targets
    Target Value
    Product Information
    Catalog Num A13114
    Formula C31H39N7O2
    Molecular Weight 541.69
    CAS Number 1346704-33-3
    SMILES CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C
    Synonyms GSK-343, GSK 343
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Solubility
    In vitro DMSO Warmed: 1 mg/mL (1.84 mM)
    Water Insoluble
    Ethanol 3 mg/mL (5.54 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.46 mL 92.3 mL 184.61 mL
    0.5 mM 3.69 mL 18.46 mL 36.92 mL
    1 mM 1.85 mL 9.23 mL 18.46 mL
    5 mM 0.37 mL 1.85 mL 3.69 mL
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    Epigenetics > Histone Methyltransferase
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