Fig. 1 · Structure
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GSK4418959 (enantiomer)
WRN Helicase Inhibitor
GSK4418959 (enantiomer) is a selective, non-covalent WRN helicase inhibitor characterized by its reversible binding properties. It effectively inhibits ATPase activity and DNA unwinding in an ATP-competitive manner. This compound is particularly valuable for researching microsatellite instability-high (MSI-H) cancers, providing insights into therapeutic strategies targeting WRN helicase.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3064599-37-4 |
| Applications | WRN Helicase Inhibitor |
| Formula | C31H30F4N4O5S |
| Molecular Weight | 646.65 |
| Synonyms | IDE275 (enantiomer) |
| SMILES | O=S(C1=CC=C(N(C(C)=N2)C)C2=C1)(N(C3=CC=C([C@@H]4CCC[C@@H]([C@H]4C(O)=O)C(NC5=C(F)C=C(C(F)(F)F)C=C5)=O)C=C3)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.