Fig. 1 · Structure
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GSK4418959
WRN Inhibitor
GSK4418959 is a selective and reversible inhibitor of the WRN helicase, exhibiting over 10,000-fold selectivity compared to other helicases. It functions as an ATP-competitive inhibitor, effectively disrupting ATPase activity and DNA unwinding processes. This compound is particularly relevant for research focused on microsatellite instability-high (MSI-H) cancers, including colorectal cancer (CRC) and endometrial cancer (EC).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3064599-36-3 |
| Applications | WRN Inhibitor |
| Formula | C31H30F4N4O5S |
| Molecular Weight | 646.65 |
| Synonyms | IDE275 |
| SMILES | O=C(NC1=CC=C(C(F)(F)F)C=C1F)[C@@H]2CCC[C@H](C3=CC=C(N(C)S(=O)(C4=CC(N=C(C)N5C)=C5C=C4)=O)C=C3)[C@H]2C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.