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GSK702

PCAF PROTAC

GSK702 is a PROTAC that targets the P300/CBP-associated factor (PCAF) with a focus on the less active cis-(S,S)-enantiomer of GSK983. This compound exhibits a modest ability to reduce PCAF protein levels and effectively binds to Cereblon (CRBN), leading to decreased interleukin-1 beta (IL-1β) levels in macrophages. GSK702 serves as a valuable tool for investigating the role of inflammatory mediators in cellular processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2260944-69-0
Applications	PCAF PROTAC
Formula	C₄₅H₅₁BrN₈O₇
Molecular Weight	895.84
SMILES	O=C(C1=CC=C([C@H]2CN(C[C@H](C2)NC(C=NN3C)=C(Br)C3=O)C)C=C1)N(C)CCCN(C)C4=CC=C(CCCOC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.