Fig. 1 · Structure
Documents & Downloads
GSK837149A
FASN Inhibitor
GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN), specifically targeting the KR domain. It exhibits reversible inhibition with a high affinity for type I FASN (Ki = 30 nM), functioning as a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A is applicable in research exploring obesity and breast cancer, providing valuable insights into metabolic regulation and tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 13616-29-0 |
| Applications | FASN Inhibitor |
| Formula | C23H22N8O5S2 |
| Molecular Weight | 554.60 |
| SMILES | O=C(NC1=CC=C(C=C1)S(=O)(NC2=NC=CC(C)=N2)=O)NC3=CC=C(C=C3)S(=O)(NC4=NC=CC(C)=N4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.