Fig. 1 · Structure
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GSK931145
GlyT
GSK931145 is a selective inhibitor of the glycine transporter 1 (GlyT1) and possesses notable anti-epileptic properties. It demonstrates a low minimum effective dose in the maximum electrical stimulation threshold test, highlighting its significant efficacy in reducing seizure activity. Additionally, GSK931145 serves as a suitable positron emission tomography (PET) radioligand for the quantitative assessment of glycine transporter availability in vivo, facilitating important neuropharmacological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 896117-64-9 |
| Applications | GlyT |
| Formula | C23H30N2O |
| Molecular Weight | 350.50 |
| SMILES | O=C(C1=C(C)C=CC=C1C)NC(C2(CCCC2)N(C)C)C3=CC=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.