GSK963

Catalog No.: A18346

RIP1 kinase inhibitor

GSK963

GSK963 Chemical Structure

CAS NO. 2049868-46-2

GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro.

Availability: In stock

Package Price Qty
5 mg
$140.00
10 mg
$230.00
50 mg
$880.00
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Biological Activity

GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro.
In vitro DMSO 41 mg/mL (178.02 mM)
Water Insoluble
Ethanol 41 mg/mL (178.02 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 43.42 mL 217.1 mL 434.2 mL
0.5 mM 8.68 mL 43.42 mL 86.84 mL
1 mM 4.34 mL 21.71 mL 43.42 mL
5 mM 0.87 mL 4.34 mL 8.68 mL

*The above data is based on the productmolecular weight 230.311. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18346
Actions Inhibitor
CAS No. 2049868-46-2
Formula C14H18N2O
M. Wt 230.311
Solubility DMSO
Purity >98%
Synonyms GSK 963, GSK-963
SMILES CC(C)(C)C(N1N=CC[[email protected]]1C2=CC=CC=C2)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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