GSK963

Catalog No.: A18346
RIP1 kinase inhibitor
GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro.
Grouped product items
Product Name Price Stock Qty
GSK963 5mg
$140.00
In stock
GSK963 10mg
$230.00
In stock
GSK963 50mg
$880.00
In stock
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Biological Activity
Discription GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro.
Product Information
Catalog Num A18346
Formula C14H18N2O
Molecular Weight 230.311
CAS Number 2049868-46-2
SMILES CC(C)(C)C(N1N=CC[C@H]1C2=CC=CC=C2)=O
Synonyms GSK 963, GSK-963
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 41 mg/mL (178.02 mM)
Water Insoluble
Ethanol 41 mg/mL (178.02 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 43.42 mL 217.1 mL 434.2 mL
0.5 mM 8.68 mL 43.42 mL 86.84 mL
1 mM 4.34 mL 21.71 mL 43.42 mL
5 mM 0.87 mL 4.34 mL 8.68 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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