GSK990 is an inactive mutant isocitrate dehydrogenase 1 (IDH1) inhibitor that exhibits no significant inhibitory activity against either wild-type or mutant IDH1/IDH2 enzymes. This compound is primarily utilized as a negative control in research studies involving the active IDH1 inhibitor GSK321. GSK990 is particularly relevant for investigations focusing on acute myeloid leukemia, enabling researchers to validate the specificity and efficacy of IDH1-targeted treatments.
GSK990 is an inactive mutant isocitrate dehydrogenase 1 (IDH1) inhibitor that exhibits no significant inhibitory activity against either wild-type or mutant IDH1/IDH2 enzymes. This compound is primarily utilized as a negative control in research studies involving the active IDH1 inhibitor GSK321. GSK990 is particularly relevant for investigations focusing on acute myeloid leukemia, enabling researchers to validate the specificity and efficacy of IDH1-targeted treatments.
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