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GSPT1 degrader-16

GSPT1 Degrader

GSPT1 Degrader-16 is a potent cereblon-based molecular glue degrader that selectively targets G1 to S phase transition 1 (GSPT1). It exhibits significant inhibitory effects on various cancer cell lines, including RS4;11, Molt4, and MM.1S, with IC50 values of 0.002, 0.26, and 0.37 μM, respectively. This compound is valuable for research applications related to cancer biology, particularly in the study of acute lymphoblastic leukemia.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3060504-68-6
Applications	GSPT1 Degrader
Formula	C₃₆H₃₀N₆O₅
Molecular Weight	626.66
SMILES	O=C(N/N=C/C1=NN(C2=C1C=CC=C2)CC3=CC=CC=C3)COC4=CC=CC=C4C5=C6C(C(N(C6)C7C(NC(CC7)=O)=O)=O)=CC=C5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.