Fig. 1 · Structure
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GSPT1 degrader-4
GSPT1 Degrader
GSPT1 degrader-4 is a molecular glue targeting GSPT1, exhibiting a DC50 value of 25.4 nM. This compound has demonstrated an IC50 of 39 nM in inhibiting the proliferation of CAL51 cells. GSPT1 degrader-4 is primarily utilized in research related to protein degradation mechanisms and can aid in studies of cellular processes related to GSPT1 function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3034764-32-1 |
| Applications | GSPT1 Degrader |
| Formula | C24H21ClN4O5 |
| Molecular Weight | 480.90 |
| SMILES | CC1=CC=C(NC(OCC2=CC=C3C(C=C(CN4C5C(NC(CC5)=O)=O)N3C4=O)=C2)=O)C=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.