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GSPT1 degrader-9

GSPT1 Molecular Glue Degrader

GSPT1 Degrader-9 is a cereblon-based molecular glue degrader that selectively targets G1 to S phase transition protein 1 (GSPT1). This compound effectively induces the degradation of GSPT1, achieving rates of 95% at 1 μM and 86% at 0.1 μM concentrations. Additionally, GSPT1 Degrader-9 demonstrates significant biological activity by inhibiting the viability of HL-60 cells, with an IC50 value of 9.2 nM, making it a valuable tool for research in cell cycle regulation and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3034310-17-0
Applications	GSPT1 Molecular Glue Degrader
Formula	C₃₇H₃₆ClN₇O₅
Molecular Weight	694.18
SMILES	O=C1NC(C(CC1)N2C(C3=CC=C(N4CC(CCN5C(N(CCC5)C6=CC(C7=C(Cl)C8=C(NC=C8CC)N=C7)=CC=C6)=O)C4)C=C3C2=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.