Fig. 1 · Structure

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GSPT2 degrader-1

GSPT2 Degrader

GSPT2 Degrader-1 is a selective molecular glue designed to target GSPT2 through a unique mechanism of action. This compound combines Thalidomide with the MDEG-541 linker, effectively inducing the degradation of GSPT2 without affecting GSPT1 or MYC. GSPT2 Degrader-1 is valuable for research applications focused on gastrointestinal cancer, offering insights into the role of GSPT2 in tumor biology and potential therapeutic interventions.

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Specifications

Manufacturer Adooq Bioscience
Actions Degrader
CAS Number 3093413-09-0
Applications GSPT2 Degrader
Formula C29H32N4O6
Molecular Weight 532.59
SMILES
O=C1CCC(C(N1)=O)N2C(C3=CC=C(C=C3C2=O)C(NCCCCCCCCNC(C4=CC=CC=C4)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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