Fig. 1 · Structure
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Gü1303
CatK Inhibitor
Gü1303 is a potent, reversible inhibitor of cathepsin K (CatK) that demonstrates a Ki of 0.91 nM for mature CatK (mCatK). This compound effectively suppresses the autocatalytic activation of the cathepsin K zymogen, making it valuable for studies related to bone resorption and various pathological conditions associated with CatK activity. Gü1303 is suitable for research applications in the fields of enzymology, pharmacology, and disease modeling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1043922-53-7 |
| Applications | CatK Inhibitor |
| Formula | C20H22N4O3 |
| Molecular Weight | 366.41 |
| SMILES | CN(N(C([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)C)C#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.