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Guanidino-G-Clamp-PNA

miR-155/TTR Inhibitor

Guanidino-G-Clamp-PNA is a sequence-specific RNA binder that targets miR-155 and transthyretin (TTR) mRNA. By reducing microRNA activity, it modulates tumor-related signaling pathways, while its interaction with TTR mRNA prevents the translation of detrimental proteins. This reagent demonstrates potent biological activity by stabilizing DNA/RNA duplexes, inducing apoptosis in cancer cells, and inhibiting tumor growth. Additionally, Guanidino-G-Clamp-PNA enhances the efficacy of splicing regulation when integrated with other oligonucleotide platforms and can be conjugated with targeting ligands for improved tissue-specific delivery. It is particularly relevant in the study of diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	476667-31-9
Applications	miR-155/TTR Inhibitor
Formula	C₅₀H₄₆N₈O₁₂
Molecular Weight	950.95

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.