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Guanosine triphosphate

Cellular Metabolism Regulator

Guanosine triphosphate (GTP) functions as a crucial nucleotide and regulator of cellular metabolism. It promotes ribosomal DNA localization, pre-rRNA transcription, and ribosome biogenesis by interacting with RNA polymerase I and GPN proteins (GPN1/3). GTP serves as a metabolic gatekeeper, linking MYC-dependent ribosome biogenesis to nucleotide availability and facilitating essential processes such as protein and nucleic acid synthesis as well as cellular signal transduction. In the context of small cell lung cancer with elevated MYC expression, GTP accumulation via the IMPDH-driven synthetic pathway influences apoptosis and cell division. GTP is investigated in studies related to small cell lung cancer, hepatoblastoma, and broader aspects of cellular metabolism.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	86-01-1
Applications	Cellular Metabolism Regulator
Formula	C₁₀H₁₆N₅O₁₄P₃
Molecular Weight	523.18
Synonyms	GTP
SMILES	O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.