Fig. 1 · Structure
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Gusperimus
Gusperimus is a synthetic racemate that targets intracellular heat shock protein hsp70, interfering with intracellular signal transduction. This mechanism enhances the efficacy of immunosuppressive therapies by inhibiting T cell differentiation into cytotoxic T cells, reducing IL-2 receptor expression on CD4 and CD8 T cells, and blocking IFN-γ-induced B cell maturation. Gusperimus demonstrates potential in transplant medicine, particularly when used in conjunction with agents such as cyclosporine, tacrolimus, or mycophenolate mofetil, to bolster immunosuppressive effects and mitigate allogeneic transplant rejection.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 98629-43-7 |
| Formula | C17H37N7O3 |
| Molecular Weight | 387.52 |
| Synonyms | 15-Deoxyspergualin |
| SMILES | O=C(NC(O)C(NCCCCNCCCN)=O)CCCCCCNC(N)=N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.