Fig. 1 · Structure
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GW 833972A free base
CB₂ Receptor Agonist
GW 833972A free base is a selective agonist of the CB₂ receptor, exhibiting a pEC₅₀ of 7.3 for the human CB₂ receptor, with a selectivity approximately 1000-fold greater than for the CB₁ receptor. This compound demonstrates the ability to inhibit induced neuronal depolarization and suppress coughing in guinea pig models. GW 833972A free base is suitable for research applications focusing on chronic cough and related respiratory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 667905-37-5 |
| Applications | CB₂ Receptor Agonist |
| Formula | C18H13ClF3N5O |
| Molecular Weight | 407.78 |
| SMILES | O=C(C1=CN=C(NC2=CC(Cl)=CC=C2)N=C1C(F)(F)F)NCC3=CC=NC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.