Fig. 1 · Structure
Documents & Downloads
GW311616 hydrochloride
HNE Inhibitor
GW311616 hydrochloride is a selective inhibitor of human neutrophil elastase (HNE), demonstrating potent activity with an IC50 value of 22 nM and a Ki value of 0.31 nM. This compound exhibits oral bioavailability and extended duration of action, making it a valuable tool for studying the role of HNE in various inflammatory diseases. Research applications include the investigation of HNE's involvement in tissue remodeling and acute lung injury.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 197890-44-1 |
| Applications | HNE Inhibitor |
| Formula | C19H32ClN3O4S |
| Molecular Weight | 433.99 |
| Synonyms | GW311616A |
| SMILES | O=C1[C@@H](C(C)C)[C@@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[C@]3([H])N1S(=O)(C)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.