Fig. 1 · Structure
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GW604714X
Mitochondrial Respiration Inhibitor
GW604714X is a highly selective inhibitor of the mitochondrial pyruvate carrier (MPC), exhibiting a dissociation constant (Ki) of less than 0.1 nM. This compound specifically disrupts mitochondrial respiration supported by pyruvate, while showing minimal impact on other substrates. Additionally, GW604714X inhibits L-lactate transport via the plasma membrane monocarboxylate transporter (MCT1) at concentrations significantly above that required for MPC inhibition. This unique profile positions GW604714X as a valuable tool for research on mitochondrial function and metabolic regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 853953-65-8 |
| Applications | Mitochondrial Respiration Inhibitor |
| Formula | C21H18FN5O5S |
| Molecular Weight | 471.46 |
| SMILES | O=C(NC/1=O)SC1=C/C2=CC(C3=NC(N4CCN(C(C)=O)CC4)=CC=C3[N+]([O-])=O)=CC=C2F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.