Fig. 1 · Structure
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Gymnemic acid I
Antisweetness Agent
Gymnemic acid I is a triterpene saponin derived from Gymnema sylvestre that functions as an antisweetness agent primarily targeting the human sweet receptor type 1 (T1R2) and T1R3. This compound exhibits significant antidiabetic properties and has been shown to inhibit ribosomal protein biosynthesis. Additionally, Gymnemic acid I induces autophagy, which protects MIN-6 pancreatic cells from apoptosis under high glucose conditions by inhibiting mTOR phosphorylation activity. Its unique mechanisms make it valuable for research in diabetes and metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 122168-40-5 |
| Applications | Antisweetness Agent |
| Formula | C43H66O14 |
| Molecular Weight | 806.98 |
| SMILES | O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1O[C@@H]2CC[C@]3(C)[C@@]4([H])CC=C5[C@]6([H])CC(C)(C)[C@H](OC(/C(C)=C/C)=O)[C@@H](O)[C@@](COC(C)=O)6[C@H](O)C[C@](C)5[C@@](C)4CC[C@]([H])3[C@@]2(C)CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.