Fig. 1 · Structure
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Gymnestrogenin
LXR Antagonist
Gymnestrogenin is a pentahydroxytriterpene derived from the leaves of Gymnema sylvestre R.Br., functioning as a liver X receptor (LXR) antagonist. It exhibits IC50 values of 2.5 μM and 1.4 μM for LXRα and LXRβ transactivation, respectively. By inhibiting LXR activity, Gymnestrogenin diminishes transcriptional activity, leading to reduced expression of mRNA. This compound is valuable for research related to metabolic regulation and the study of cholesterol homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 19942-02-0 |
| Applications | LXR Antagonist |
| Formula | C30H50O5 |
| Molecular Weight | 490.72 |
| SMILES | OC[C@]1(C[C@H](O)C(C)(C)C2)[C@]2([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(CC[C@H](O)[C@@]5(C)CO)C)[C@]3(C)C[C@@H]1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.