Fig. 1 · Structure
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GyrB-IN-1
GyrB Inhibitor
GyrB-IN-1 is a selective inhibitor of DNA gyrase (GyrB), specifically targeting its ATPase activity. With an IC50 of 19.1 μM against Mycobacterium smegmatis GyrB and 21.9 μM against Mycobacterium tuberculosis GyrB DNA supercoiling activity, GyrB-IN-1 demonstrates effective antimycobacterial properties. This compound is a valuable tool for research focused on tuberculosis and provides insights into the mechanisms of GyrB inhibition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1870007-38-7 |
| Applications | GyrB Inhibitor |
| Formula | C21H12ClN3O2S |
| Molecular Weight | 405.86 |
| SMILES | O=C(C1=CC=C(C=C1)C2=CC=C(S2)/C=C(C#N)/C3=NC4=CC(Cl)=CC=C4N3)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.